Specific repression of -globin promoter activity by nuclear ferritin

Specific repression of beta-globin promoter activity by nuclear ferritin.

Developmental hemoglobin switching involves sequential globin gene activations and repressions that are incompletely understood. Earlier observations, described herein, led us to hypothesize that nuclear ferritin is a repressor of the adult beta-globin gene in embryonic erythroid cells. Our data show that a ferritin-family protein in K562 cell nuclear extracts binds specifically to a highly con...

Tissue Specific Expression of Human Calcitonin Gene in Potato Tubers by an Organ Specific Promoter

To increase the production level of heterologous proteins in plants, strategies such as choice of strongerpromoters, optimization of codon usage and specific localization of foreign proteins are of major concern.Calcitonin (CT), a 32 amino acid polypeptide is a powerful and specific inhibitor of bone resorption and isused to treat several human diseases. Calcitonin activity is...

Acetylation of a Specific Promoter Nucleosome Accompanies Activation of the ε-Globin Gene by b-Globin Locus Control Region HS2

Down Regulation of DHFR Promoter Activity by PML Transcription Repressor

Activation of beta-globin promoter by erythroid Krüppel-like factor.

Erythroid Krüppel-like factor (EKLF), an erythroid tissue-specific Krüppel-type zinc finger protein, binds to the beta-globin gene CACCC box and is essential for beta-globin gene expression. EKLF does not activate the gamma gene, the CACCC sequence of which differs from that of the beta gene. To test whether the CACCC box sequence difference is the primary determinant of the selective activatio...